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Early inflammatory responses include the migration of neutrophils and macrophages, production of pro-inflammatory cytokines and chemokines such as TNF-α, IL-1, and IL-6 at different stages of HF (157), mediation of myocardial cell necrosis and exacerbation of adverse cardiac remodeling (158), making the targeted inhibition of neutrophil-derived pro-inflammatory factors an active area of research for treating HF

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However, because HD affects the entire brain, broader delivery to cortical and other regions may be required for effective treatment